The Galaxy Evolution Explorer

The Galaxy Evolution Explorer (GALEX), a NASA Small Explorer Mission planned for launch in Fall 2002, will perform the first Space Ultraviolet sky survey. Five imaging surveys in each of two bands (1350-1750Å and 1750-2800Å) will range from an all-sky survey (limit m_(AB)~20-21) to an ultra-deep survey of 4 square degrees (limit m_(AB)~26). Three spectroscopic grism surveys (R=100-300) will be performed with various depths (m_(AB)~20-25) and sky coverage (100 to 2 square degrees) over the 1350-2800Å band. The instrument includes a 50 cm modified Ritchey-Chrétien telescope, a dichroic beam splitter and astigmatism corrector, two large sealed tube microchannel plate detectors to simultaneously cover the two bands and the 1.2 degree field of view. A rotating wheel provides either imaging or grism spectroscopy with transmitting optics. We will use the measured UV properties of local galaxies, along with corollary observations, to calibrate the UV-global star formation rate relationship in galaxies. We will apply this calibration to distant galaxies discovered in the deep imaging and spectroscopic surveys to map the history of star formation in the universe over the red shift range zero to two. The GALEX mission will include an Associate Investigator program for additional observations and supporting data analysis. This will support a wide variety of investigations made possible by the first UV sky survey

A rapid controller of temperature for use in determining Arrhenius profiles in biomembrane systems

To minimize artifacts in temperature-velocity (Arrhenius) profiles due to aging of preparations of biological membranes, a rapid controller of temperature was developed for spectrophotometric or polarographic (O 2 electrode) measurements. The reaction mixture is cooled or heated through contact with Peltier elements. One Pt temperature sensor in the cuvette or electrode holder controls current flow into the Peltier units, and another Pt temperature sensor in the reaction mixture is used to read out the sample temperature on a meter or recorder, and to provide feedback control. The sample temperature can be reproducibly set to within 0.1°C, with a noise level of 0.04°C or less; a change of 4°C takes 1 min.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44794/1/10863_2004_Article_BF00744744.pd

The Galaxy Evolution Explorer

The Galaxy Evolution Explorer (GALEX), a NASA Small Explorer Mission planned for launch in Fall 2002, will perform the first Space Ultraviolet sky survey. Five imaging surveys in each of two bands (1350-1750Å and 1750-2800Å) will range from an all-sky survey (limit m_(AB)~20-21) to an ultra-deep survey of 4 square degrees (limit m_(AB)~26). Three spectroscopic grism surveys (R=100-300) will be performed with various depths (m_(AB)~20-25) and sky coverage (100 to 2 square degrees) over the 1350-2800Å band. The instrument includes a 50 cm modified Ritchey-Chrétien telescope, a dichroic beam splitter and astigmatism corrector, two large sealed tube microchannel plate detectors to simultaneously cover the two bands and the 1.2 degree field of view. A rotating wheel provides either imaging or grism spectroscopy with transmitting optics. We will use the measured UV properties of local galaxies, along with corollary observations, to calibrate the UV-global star formation rate relationship in galaxies. We will apply this calibration to distant galaxies discovered in the deep imaging and spectroscopic surveys to map the history of star formation in the universe over the red shift range zero to two. The GALEX mission will include an Associate Investigator program for additional observations and supporting data analysis. This will support a wide variety of investigations made possible by the first UV sky survey

American Gut: an Open Platform for Citizen Science Microbiome Research

McDonald D, Hyde E, Debelius JW, et al. American Gut: an Open Platform for Citizen Science Microbiome Research. mSystems. 2018;3(3):e00031-18

Determining PPN gamma with Gaia's astrometric core solution

The ESA space astrometry mission Gala, due for launch in early 2012, will in addition to its huge output of fundamental astrometric and astrophysical data also provide stringent tests of general relativity. In this paper we present an updated analysis of Gaia's capacity to measure the PPN parameter gamma as part of its core astrometric solution. The analysis is based on small-scale astrometric solutions taking into account the simultaneous determination of stellar astrometric parameters and the satellite attitude. In particular, the statistical correlation between PPN gamma and the stellar parallaxes is considered. Extrapolating the results to a full-scale solution using some 100 million stars, we find that PPN gamma could be obtained to about 10(-6), which is significantly better than today's best estimate from the Cassini mission of 2 x 10(-5)

Éruptions eczématiformes chroniques du sujet âgé : quelle imputabilité médicamenteuse ?

International audienceLe rôle des médicaments dans la survenue d’éruptions eczématiformes du sujet âgé (EESA) a été suggéré dans une étude cas-témoin française montrant une fréquence de prise des inhibiteurs calciques de 26 % chez les patients ayant une EESA (OR de 2,5 par rapport aux témoins sans eczéma). Ces résultats ont ensuite été confirmés par une étude rétrospective américaine. Des cas isolés d’EESA ont depuis été rapportés avec le clopidogrel, les IEC, les ARAII et les diurétiques. Notre étude initiale ayant été réalisée il y a 15 ans, nous en avons réalisé une nouvelle pour réévaluer l’association entre les prises médicamenteuses et les EESA

movie_s2.mp4

Placing changes in the microbiome in the context of the American Gut. We accumulated samples over sequencing runs to demonstrate the structural consistency in the data. We demonstrate that while the ICU dataset (https://www.ncbi.nlm.nih.gov/pubmed/27602409) falls within the American Gut samples, they do not fall close to most samples at any of the body sites. We then highlight samples from the United Kingdom, Australia, the United States and other countries to show that nationality does not overcome the variation in body site. We then highlight the utility of the American Gut in meta-analysis by reproducing results from (https://www.ncbi.nlm.nih.gov/pubmed/20668239) and (https://www.ncbi.nlm.nih.gov/pubmed/23861384), using the AGP dataset as the context for dynamic microbiome changes instead of the HMP dataset. We show rapid, complete recovery of C. diff patients following fecal material transplantation and also contextualized the change in an infant gut over time until it settles into an adult state. This demonstrates the power of the American Gut dataset, both as a cohesive study and as a context for other investigations

ag_tree.tre

The SEPP (Mirarab et al Pac Symp Biocomput 2012) fragment insertion tree used for phylogenetic analyses

Unweighted UniFrac distances

The unweighted UniFrac distance (Lozupone and Knight AEM 2005) matrix of the 9511 fecal samples used in the American Gut paper. UniFrac was computed using Striped UniFrac (https://github.com/biocore/unifrac). Prior to execution of UniFrac, Deblur (Amir et al mSystems 2017) was run on the samples, all bloom sOTUs were removed (Amir et al mSystems 2017), and samples were rarefied to a depth of 1250 reads (Weiss et al Microbiome 2017). For the phylogeny, fragments were inserted using SEPP (Mirarab et al Pac Symp Biocomput 2012) into the Greengenes 13_5 99% OTU tree (McDonald et al ISME 2012)